… Inserting CIDR. I gave my goat a rediculous amount of calcium and then I … after injection. Never inject straight in at 90 degrees. I have to … Rectal temperature was elevated about 1.5° F through the 6th hour after injection with 250 mg dinoprost, but had returned to baseline at 24 hours after injection. Prostaglandins, especially PGE’s and PGF’s, have been shown, in certain species, to 1) increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2) stimulate myometrial activity, and 3) to induce either abortion or parturition. gov/AnimalVeterinary/SafetyHealth. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Her last kidding she had concerned me because she was having contractions for hours, with no pushing and no progress. Almost all shots for goats can be given SQ* (even if the label says IM) with the exception of hormones, such as Lutalyse. Do not use in horses intended for human consumption. Average rectal temperature during the periods of decreased temperature was on the order of 97.5 to 99.6, with the greatest decreases observed in the 10 mg dose group. The response to treatment varies by individual animals with a mean interval from administration of 2 mL LUTALYSE Injection (10 mg dinoprost) to parturition of approximately 30 hours. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection. It would also be a good idea to treat her to prevent uterine infection. The 30 mL bottle may be used for cattle, swine, or mares. As much as I prefer doing things naturally, I was very happy with my first experience using lute, and will be using it regularly in the future to encourage predictable and easier kiddings. How much calcium are you giving her. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. The next day, at 30 hours post-lute, Gia delivered healthy twins, completely unassisted between our check-ups. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. 5 ml to young kids for prevention of Enterotoxemia (gives 10-14 day passive immunity) 3 ml up to … Following abortion, early fetal death and resorption, or as a result of “pseudopregnancy”, there may be serum progesterone levels consistent with a functional corpus luteum. Authors: … In rare instances, such infections have resulted in death. Guide D-704 Reviewed by Chris Allison and Robert G. Hagevoort College of Agricultural, Consumer and Environmental Sciences, New Mexico State University. Use only sterile needles, and use each needle only once. LUTALYSE Injection is available in 30 and 100 mL vials. Some of these factors are: a. General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. 4. For Difficult-to-Breed Mares: In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5 mg LUTALYSE Injection; ovulation occurred an average of 7.0 days after treatment. Create your own unique website with customizable templates. For Estrus Synchronization in Beef Cows, Beef Heifers and Replacement Dairy Heifers. If she is not cycling there will not be a CL to lyse. If the cow returns to estrus, breed at the usual time relative to estrus. Gia’s udder began to slowly fill throughout the day, and by the night, her ligaments had softened. At mid gestation we would recommend giving ten cc of two mg Dexamethasone in addition to three cc of Lutalyse. Prostaglandins have been reported to result in release of pituitary tropic hormones. Cattle expressing estrus following LUTALYSE Injection are receptive to breeding by a bull. The kids were small enough to be passed with ease by their mothers, but mature enough to be healthy and active. These effects are usually seen within 15 minutes of injection and disappear within one hour. This was due to the expected luteolytic properties of the drug. If given to a pregnant cow, it may cause abortion; the dose required for abortion varies considerably with the stage of gestation. She went into natural labor a couple days over 145, and for the first time ever, she needed vet assistance. Route of administration for each dose group was both intramuscularly (2 mares) and subcutaneously (2 mares). She had plenty of colostrum, and we couldn’t have been happier with the results. Providing 20 hr of light per day in January and February (northern USA), with a sudden return to available daylight on March 1, will bring goats into estrus several weeks later. 7. There was no evidence of toxicological effects. Doses of 2.5 to 20 mg PGF have been used, with the higher doses giving a more predictable time of parturition. At luteolytic doses, dinoprost had no effect on progeny. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Treatment of “anestrous” mares which abort subsequent to 36 days of pregnancy may not result in return to estrus due to presence of functional endometrial cups. Other measurements evaluated in the study remained within normal limits. After 14 days, recovery rate of treated cattle was no different than that of non-treated cattle. There was no unequivocal effect of dinoprost on the hematology or clinical chemistry parameters measured. This procedure may be utilized as an aid to scheduling the use of stallions. In other words, if the goat … Since I had a lot of does to treat and lutalyse is not … Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. In this system, it is more difficult … I would call the vet in the morning and find out what they gave you. I figured we'd wait a couple more hours to see if she progressed to more consistent contractions and pushing. For use with FACTREL® (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: For a full description of the studies conducted for the use of FACTREL Injection and LUTALYSE Injection, please refer to the labeling for FACTREL Injection. Sweating was temporary in all cases and was mild for doses of 3.0 mg or less but was extensive (beads of sweat over the entire body and dripping) for the 10 mg dose. Rabies is required to be given IM, and the large rear leg muscle is an ideal site. Use of this product in excess of the approved dose may result in drug residues. These data support previous reports that dinoprost has a half-life of minutes. Using bulls to breed large numbers of cattle in heat following LUTALYSE Injection will require proper management of bulls and cattle. With the doe trembling, I'd give 30 cc injectable calcium subQ. However, these have been transient in all cases observed and have not been detrimental to the animal. I was beginning to be concerned that the same thing was happening this year. Post by Brandywine onFeb 24, 2009 at 7:27pm. To top it off, she had completely and adamantly refused my help. For this reason, the 100 mL bottle should only be used for cattle. Data suggest prostaglandins, especially PGE’s and PGF’s, may be involved in the process of ovulation and gamete transport. Swine: The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. All systems associated with dinoprost metabolism exist in the body; therefore, no new metabolic, transport, excretory, binding or other systems need be established by the body to metabolize injected dinoprost. Not necessarily, but I will say that none of my concerns about lute were realized. Mares: LUTALYSE Injection is indicated for its luteolytic effect in mares. In mares, LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation. Thank you for sharing your knowledge, this is great information. LUTALYSE® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. A couple of vets have told me that there is no reason to ever give … Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. At these doses, kidding may be expected in 30 to 36 hours. 5. Do not administer intravenously (IV) as this route may potentiate adverse reactions. With the single injection, cattle should … 5 mg dinoprost/mL as dinoprost tromethamine. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. If estrus has not been … How much Lutalyse should I give my heifer? Use directions on bag. Day 10. That idea didn’t appeal to me, so I didn’t give induction further thought. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. • Inject 5 mL LUTALYSE Injection (equivalent to 5 mg/mL dinoprost) 1 day prior to EAZI-BREED CIDR Cattle Insert removal, on Day 6 of the 7 day administration period. Mares: Dinoprost tromethamine was administered to adult mares (weighing 320 to 485 kg; 2 to 20 years old), at the rates of 0, 100, 200, 400, and 800 mg per mare per day for 8 days. No apparent differences were observed between the intramuscular and subcutaneous routes of administration. User Safety: Not for human use. For Treatment of Pyometra (chronic endometritis) in Cattle: In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Sweating after the 5.0 mg dose was intermediate between that seen for mares treated with 3.0 and 10.0 mg. Sweating began within 15 minutes after injection and ceased by 45 to 60 minutes after injection. No vial stopper should be entered more than 20 times. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Day 7. A slight and marked embryo lethal effect was observed in dams given 1.0 and 5.0 mg dinoprost/kg/day respectively. The percent of pregnant cattle in each feedlot less than 100 days of gestation ranged between 26 and 84; 80% or more of the pregnant cattle were less than 150 days of gestation. The kids were too large, and tangled up. Mares usually continue to eat during the period of expression of side effects. ​             The thought of inducing an animal into labor can be a scary one. This information is essential to determine the appropriate time for administration of LUTALYSE Injection. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment. A proportion of “barren”, maiden, and lactating mares do not exhibit regular estrous cycles and may be in extended diestrus. In cycling goats, luteolysis may be induced by administration of PGF 2α (2.5–5 mg, IM) or cloprostenol (62.5–125 mcg, IM) as early as day 3. LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Federal law restricts this drug to use by or on the order of a licensed veterinarian.For intramuscular use for estrus synchronization, treatment of unobserved (silent) estrus and pyometra (chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine; and for controlling the timing of estrus in estrous cycling mares and clinically anestrous mares that have a corpus luteum. Metabolism: A number of metabolism studies have been done in laboratory animals. Mares treated with either 400 mg or 800 mg exhibited more profound symptoms. So we gave Gia her shot, and the waiting game began. Laboratory Animals: Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. The use of CIDRs in goats has been demonstrated to efficiently induce and synchronize estrus and ovulation during the breeding as well as the non-breeding seasons. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. Vaginal … Turns out, when she finally let me help her, she hadn’t dilated. This is not my first choice of product to use, because … Cattle serum collected during 24 hours after doses of 0 to 250 mg dinoprost have been assayed by RIA for dinoprost and the 15-keto metabolites. For Parturition Induction in Swine: For intramuscular use for parturition induction in swine. Personally, I daily dose each affected goat individually by mixing the mineral with molasses to make a paste and sandwich the mixtures between animal cookies or Ritz crackers. Our second doe due was Twinkles. It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum in the following circumstances: 1. All Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Clinically, a slight transitory increase in heart rate was detected. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. Many factors contribute to success and failure of reproduction management, and these factors are important also when time of breeding is to be regulated with LUTALYSE Injection. Trimming CIDR tail. Once you draw out the PG 600 into each syringe … For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda. Turns out that whatever the issue was, that second dose of lute was exactly what she needed. Treatment dosage: Mix 1 oz CoRid in 5 oz. 6. If we give it in the morning 9-10 am, they have been calving from 24 hrs to 40 hours later. Sweating was observed for 0 of 9, 2 of 9, 7 of 9, 9 of 9, and 8 of 9 mares injected with 0.25, 1.0, 2.5, 3.0, 5.0, or 10.0 mg dinoprost tromethamine, respectively. We have Boer goats so we use between 1.25ml and 1.50ml per doe. Goat synchronization program for use during the "natural" season. A study demonstrated that equimolar doses of 3H PGF2 alpha Tham and 3H PGF2 alpha free acid administered intravenously to rats demonstrated no significant differences in blood concentration of dinoprost. Inject a dose of 5 mL LUTALYSE (25 mg PGF2α) intramuscularly either once or twice at … For Treatment of Pyometra (chronic endometritis) in Cattle. If she is a dairy goat who only comes into heat in the fall, it may be too early, if she is another breed of goat … However, she warned me that induction can cause malpresentation during labor, as whatever position the kid happens to be in was the position they’d be pushed out in. I wouldn't inject glucose, but it wouldn't hurt to either give her some warm water containing Karo syrup or molasses, or a few pumps of NutraDrench. Of those mares bred, 59% were pregnant following an average of 1.4 services during that estrus. The half-life of dinoprost in bovine blood has been reported to be on the order of minutes. For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers: • Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday). If artificial insemination … Mares did not appear to sustain adverse effects following termination of the side effects. Goat dose: SQ Injection. The abortion rates following injection of LUTALYSE Injection increased with increasing doses up to about 25 mg. As examples, the abortion rates, over 7 feedlots on the dose titration study, were 22%, 50%, 71%, 90% and 78% for cattle up to 100 days of gestation when injected IM with LUTALYSE Injection doses of 0,1 (5 mg), 2 (10 mg), 4 (20 mg) and 8 (40 mg) mL, respectively. Common Goat Medications and "Easy to Understand" Dosages Wormers Product "Vet" Dose Labeled Dose Typical Goat Dose Comments Valbazen 7.5 mg/kg 3cc/100lbs 5cc/100lbs Do not use in early pregnancy (if at all); effective vs. tapeworms Safe-Guard 5 mg/kg 2.3cc/100lbs 5cc/100lbs Use in goats … If estrus has not been observed by 80 hours after injection, breed at 80 hours. The smallness of the fetus at this early stage of gestation should not lead to complications at abortion. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Luteolytic doses of dinoprost tromethamine are on the order of 5 to 10 mg administered on one day, therefore, LUTALYSE Injection was demonstrated to have a wide margin of safety. Day 11. Protect from freezing. I give … We also feed the cows about 5 pm to help reduce nighttime calving but inducing seems to mess that up. Artificial Insemination of Dairy Goats. For use with EAZI-BREED™ CIDR® (progesterone intravaginal insert) Cattle Insert for Synchronization of Estrus in Lactating Dairy Cows: • Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday). This can be employed to control the time of farrowing in sows and gilts in late gestation. LUTALYSE Injection is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. Store at controlled room temperature 20° to 25°C (68° to 77°F). Everything I’d read said to give 2ccs of lute as an intramuscular injection, and to expect kids within 36 hours. Do not administer to sows and/or gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. Breed. Thus, the 100 mg dose gave a safety margin of 10 to 20X for a single injection or 80 to 160X for the 8 daily injections. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers: Commercial cattle were palpated per rectum for pregnancy in six feedlots. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 48 hours before removing the CIDR they recommend injecting 200-400 IU of PG600 IM … *Due to the nature of how goats are put together by nature, and how they metabolize … One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. With the single injection, cattle should be bred at the usual time relative to estrus. Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. This product provides short-term protection (just a few hours) but works quickly. The mothers both produced plenty of colostrum, and passed their placentas with no issue. No mortality occurred in any of the groups. Management Considerations: Several factors must be considered for the successful use of LUTALYSE Injection for parturition induction in swine. However, such bone changes were not observed in monkeys similarly administered LUTALYSE Injection at 15 mg dinoprost per kg body weight for 14 days. Prostaglandins, especially PGF2α, have been shown to 1) increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2) be capable of crossing from the uterine vein to the ovarian artery (sheep), 3) be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Illnesses Unlike Gia, Manchi’s pre-labor seemed to stretch on for ages. Lutalyse® Injection (dinoprost tromethamine injection) 5 mg dinoprost/mL as dinoprost tromethamine Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Also PGF2α has been reported to cause increase in blood pressure, bronchoconstriction, and smooth muscle stimulation in certain species. Select one or more newsletters to continue. CIDR-G in Lutalyse. CIDR-G out + 200 eCG. No preslaughter drug withdrawal period is required for labeled uses in swine. Dinoprost is a natural prostaglandin. Additional studies investigated the effects in the mare of single intramuscular doses of 0, 0.25, 1.0, 2.5, 3.0, 5.0, and 10.0 mg dinoprost tromethamine. 5cc lutalyse and 10cc Dex is all it takes here. Distributed by: Zoetis Inc., Kalamazoo, MI 49007, Copyright © 2021 Animalytix LLC. A complete study on the distribution of decline of 3H PGF2 alpha Tham in the tissue of rats was well correlated with the work done in the cow. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. The results indicated no treatment related effects from dinoprost treatment that were deleterious to the health of the animals or to their offspring. Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less based on palpation per rectum at 14 and 28 days. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. Cattle: LUTALYSE Injection is indicated as a luteolytic agent. Cattle: Limited salivation has been reported in some instances. Symptoms. A 14-day continuous intravenous infusion study in rats at 20 mg PGF2α per kg body weight indicated prostaglandins of the F series could induce bone deposition. Induction of abortion in feedlot cattle at stages of gestation up to 100 days of gestation did not result in dystocia, retained placenta or death of heifers in the field studies. Every effort has been made to ensure the accuracy of the Lutalyse Injection information published above. As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Dinoprost tromethamine is a white or slightly off-white crystalline powder that is readily soluble in water at room temperature in concentrations to at least 200 mg/mL. In the early stages, women may be unaware of their pregnancies. Linda Cortright wrote in Cash Mirror 2 years ago that her stand-in vet recommended 5 cc per goat, but didn't Lydia Ratcliffe a long time ago say 0.8 cc? Changes were detected in all treated groups for clinical (reduced sensitivity to pain; locomotor incoordination; hypergastromotility; sweating; hyperthermia; labored respiration), blood chemistry (elevated cholesterol, total bilirubin, LDH, and glucose), and hematology (decreased eosinophils; increased hemoglobin, hematocrit, and erythrocytes) measurements. Dr Steve : Cornell University has a protocol that involves putting the sheep/goat CIDR in for 18-21 days. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously at doses of 0.5 and 1.0 mg dinoprost/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14 or 15, 16 and 17 or orally at doses of 0.01, 0.1 and 1.0 mg dinoprost/kg/day on days 6-18 or 5.0 mg/kg/day on days 8-18 of gestation. For kids, give 1 to 3 cc orally every 12 hours until goat berries are normal. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. The effects in the 100 mg dose, and to a lesser extent, the 200 mg dose groups were transient in nature, lasting for a few minutes to several hours. Day 0. For treatment of unobserved estrus, inject a 5 mL dose IM. I would repeat the injection with 2ml per doe 7-10 days after the first injection. About 5 hours after her second shot, she delivered healthy twins as I was power-napping between check-ups. Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above: 2nd FACTREL + FTAI at 48 hours after LUTALYSE. However, induction of parturition or abortion with any exogenous compound may precipitate dystocia, fetal death, retained placenta and/or metritis, especially at latter stages of gestation. Most cattle that recovered in response to LUTALYSE Injection recovered within 14 days after injection. These side effects are transitory, lasting from 10 minutes to 3 hours, and were not detrimental to the health of the animal. When I first began my goat journey, I was told by a fellow breeder that she induced her does so she’d know when to expect the kids. Should we all start inducing our goats? Contact Information: To report adverse reactions call Zoetis Inc. at 1-888-963-8471. Cattle: In cattle, evaluation was made of clinical observations, clinical chemistry, hematology, urinalysis, organ weights, and gross plus microscopic measurements following treatment with various doses up to 250 mg dinoprost administered twice intramuscularly at a 10 day interval or doses of 25 mg administered daily for 10 days. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. I appreciate your diagrams on good intra-muscular injection sites! Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. For estrus synchronization, inject 5 mL LUTALYSE intramuscularly (IM) either once or twice at 10- to 12-day intervals. Heart rate, respiration rate, rectal temperature, and sweating were measured at 0, 0.25, 0.50, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, and 6.0 hr. I was taught that the way to avoid hitting the sciatic nerve is to change the angle of injection. No dinoprost associated gross lesions were detected. A follow-up study was conducted at NCSU using 87 Boer and Boer-crossbred does that were divided into four treatment groups: Heat Check method described above, CIDR Method described above, NC Synch with TAI at 48 hours after the second Lutalyse injection (NC Synch 48) and NC Synch method with TAI at 72 hours after second Lutalyse … Put the needle in PARALLEL to the muscle with the tip pointed down. 2cc is the dose, … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Cattle must be ready to breed-they must have a corpus luteum and be healthy; b. Nutritional status must be adequate as this has a direct effect on conception and the initiation of estrus in heifers or return of estrous cycles in cows following calving; c. Physical facilities must be adequate to allow cattle handling without being detrimental to the animal; d. Estrus must be detected accurately if timed Al is not employed; A successful breeding program can employ LUTALYSE Injection effectively, but a poorly managed breeding program will continue to be poor when LUTALYSE Injection is employed unless other management deficiencies are remedied first.

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